MEDICINE RESEARCH / CANNABIS
CANNABIS
Library
Broad reviews, product composition, clinical trials, mental health, and long-term observation—with links to original cannabis and cannabinoid research.
Cannabis plants, high-THC products, purified CBD, and standardized cannabinoid medicines are distinguished, together with study design and population.
CURATED READING ORDER
Cannabis resources
- 01Umbrella reviewDetailed introduction
Balancing Risks and Benefits of Cannabis Use: Umbrella Review of Meta-Analyses of Randomised Controlled Trials and Observational Studies
Balancing risks and benefits of cannabis use: umbrella review of meta-analyses of randomised controlled trials and observational studies
A detailed introduction to a 2023 BMJ paper that examined 101 meta-analyses on cannabis and cannabinoids, evaluating evidence of benefits and harms within the same framework.
Marco Solmi et al. · BMJ · 2023
- 02Systematic reviewDetailed introduction
High-Concentration Delta-9-Tetrahydrocannabinol Cannabis Products and Mental Health Outcomes: A Systematic Review
High-Concentration Delta-9-Tetrahydrocannabinol Cannabis Products and Mental Health Outcomes: A Systematic Review
A detailed introduction to a 2025 review evaluating associations between high-concentration THC products and psychosis, anxiety, depression, cannabis use disorder, and other outcomes across 99 studies involving more than 220,000 people.
Phunsup W. Rittiphairoj et al. · Annals of Internal Medicine · 2025
- 03Biochemical and receptor studyDetailed introduction
Isolation and Structure of a Brain Constituent That Binds to the Cannabinoid Receptor
Isolation and structure of a brain constituent that binds to the cannabinoid receptor
A detailed introduction to the 1992 Science paper that isolated and identified anandamide, an endogenous lipid that binds to the cannabinoid receptor, from porcine brain.
William A. Devane et al. · Science · 1992
- 04Repeated cross-sectional chemical analysisDetailed introduction
Changes in Cannabis Potency Over the Last 2 Decades (1995–2014): Analysis of Current Data in the United States
Changes in Cannabis Potency Over the Last 2 Decades (1995–2014): Analysis of Current Data in the United States
A detailed introduction to a 2016 study that analyzed 38,681 cannabis samples seized in the United States and reported 20-year changes in THC concentration and the THC-to-CBD ratio.
Mahmoud A. ElSohly et al. · Biological Psychiatry · 2016
- 05Chemical analysis of commercial productsSource-aligned translation
Product Labeling Accuracy and Contamination Analysis of Commercially Available Cannabidiol Product Samples
Product labeling accuracy and contamination analysis of commercially available cannabidiol product samples
A source-aligned translation of a 2024 study that measured agreement with labeled content and tested for heavy metals, residual solvents, pesticides, and other contaminants in 202 CBD products obtained in the United States.
Barry E. Gidal et al. · Frontiers in Pharmacology · 2024
- 06Double-blind randomized placebo-controlled trialDetailed introduction
Trial of Cannabidiol for Drug-Resistant Seizures in the Dravet Syndrome
Trial of Cannabidiol for Drug-Resistant Seizures in the Dravet Syndrome
A detailed introduction to a 2017 double-blind trial in 120 children and young people with Dravet syndrome that compared purified CBD added to standard treatment with placebo.
Orrin Devinsky et al. · The New England Journal of Medicine · 2017
- 07Multicentre case-control studySource-aligned translation
The Contribution of Cannabis Use to Variation in the Incidence of Psychotic Disorder Across Europe (EU-GEI): A Multicentre Case-Control Study
The contribution of cannabis use to variation in the incidence of psychotic disorder across Europe (EU-GEI): a multicentre case-control study
A source-aligned translation of the EU-GEI study comparing 901 people with a first episode of psychosis and 1,237 controls to examine associations with cannabis-use frequency and estimated THC potency.
Marta Di Forti et al. · The Lancet Psychiatry · 2019
- 08Systematic review and meta-analysisDetailed introduction
Medical Cannabis or Cannabinoids for Chronic Non-Cancer and Cancer-Related Pain: A Systematic Review and Meta-Analysis of Randomised Clinical Trials
Medical cannabis or cannabinoids for chronic non-cancer and cancer related pain: a systematic review and meta-analysis of randomised clinical trials
A detailed introduction to a 2021 BMJ review that aggregated 32 randomized trials involving 5,174 people and assessed benefits and adverse events of medical cannabis or cannabinoids for chronic pain.
Li Wang et al. · BMJ · 2021
- 09Randomized placebo-controlled trialDetailed introduction
Cannabis in Painful HIV-Associated Sensory Neuropathy: A Randomized Placebo-Controlled Trial
Cannabis in painful HIV-associated sensory neuropathy: a randomized placebo-controlled trial
A detailed introduction to a 2007 trial that compared inhaled cannabis with placebo for 5 days in 55 people with painful HIV-associated sensory neuropathy.
Donald I. Abrams et al. · Neurology · 2007
- 10Prospective birth-cohort studyDetailed introduction
Persistent Cannabis Users Show Neuropsychological Decline from Childhood to Midlife
Persistent cannabis users show neuropsychological decline from childhood to midlife
A detailed introduction to a 2012 study that followed a New Zealand birth cohort of 1,037 people to age 38 and examined the association between persistent cannabis use and neuropsychological change.
Madeline H. Meier et al. · Proceedings of the National Academy of Sciences · 2012